Pathologic Basis of Disease

The 4th edition of this textbook, now in full color, presents both general pathology and special pathology in one comprehensive resource. Coverage includes a brief review of basic principles related to anatomy, structure and function, followed by congenital and functional abnormalities and discussions of viral, bacterial, and parasitic infections and neoplasia.

This new edition is praiseworthy for the breadth and depth of its content and its ability to remain up to date. It serves the needs not only of the beginning student, the pathologist in training, but all practitioners of medicine with intellectual curiosity.

Physiological Basis of Respiratory Disease covers the important areas of respiratory physiology of particular relevance for pulmonary fellows and academic physicians. The text provides a solid basis for the understanding of the physiological basis for the major respiratory diseases. The contents are based on past and present research strengths of the Meakins Christie Laboratories with the majority of contributors comprised of former alumni. Physiological Basis of Respiratory Disease features a unique collection of topics, spanning classical physiological concepts to present day research. The clinical relevance of various research findings is examined and interpreted for the reader. Presented in an accessible format, need-to-know information is supported by a thorough selection of illustrations and references. The text is also applicable to other fields such as physiotherapy and inhalation therapy. ...

Substantial morbidity and mortality remains associated with thrombotic events has stimulated the rapid expansion of the available armamentarium to combat pathologic thrombosis. Pathologic thrombosis plays an essential role in the pathogenesis of acute coronary syndromes (ACS), ischemic complications of percutaneous coronary intervention (PCI), venous thromboembolic disease, and embolic complications of arrhythmias and various cardiomyopathies.

Ultrasonography (US) has long been considered an important diagnostic imaging modality for investigation of the pancreas despite certain significant and well-known limitations. Indeed, in many countries US represents the first step in the diagnostic algorithm for pancreatic pathologies. Recent years have witnessed major advances in conventional, harmonic, and Doppler imaging. New technologies, softwares, and techniques, such as volumetric imaging, enhancement quantification, and fusion imaging, are increasing the diagnostic capabilities of US. The injection of microbubble contrast agents allows better tissue characterization with definitive differentiation between solid and cystic lesions.

In this volume Dr. Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations.

The second half of the twentieth century witnessed the emergence of a new model of chronic disease—diagnosed on the basis of numerical deviations rather than symptoms and treated on a preventive basis before any overt signs of illness develop—that arose in concert with a set of safe, effective, and highly marketable prescription drugs. In Prescribing by Numbers, physician-historian Jeremy A. Greene examines the mechanisms by which drugs and chronic disease categories define one another within medical research, clinical practice, and pharmaceutical marketing, and he explores how this interaction has profoundly altered the experience, politics, ethics, and economy of health in late-twentieth-century America. ...

Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease. ...

Huntington's disease, or Huntington's chorea, is a progressive genetic disease marked by death of brain cells coupled with loss of muscular control and coordination, declining mental abilities, and erratic behavior. Currently, this form of dementia has no cure. "Huntington's Disease" introduces this disease, detailing its history and progression, and discusses the search for the gene that causes it and the development of genetic tests for the gene. This title also addresses the ethical questions of testing people for a disease whose symptoms typically develop later in life.

Celiac Disease For Dummies is the ultimate reference for people with the disease and their family members. The book helps readers identify symptoms of the disease, and explains how doctors definitively diagnose celiac disease. It outlines how celiac disease affects the body, and what its consequences could be if untreated.

This book is the first to review in depth the neurobiological and clinical characteristics of memory and its disorders in neurodegenerative disease. It presents current information about memory disorders in Alzheimer's, Huntington's and Parkinson's diseases and in other neurological conditions such as progressive supranuclear palsy, Creutzfeld-Jacob disease and HIV-associated dementia. The contributors are among the most distinguished working in this field. They present the neuroanatomical and neurochemical basis of memory disorders in neurodegenerative disease, and review the contribution of neuroradiology and neuropathology to the understanding of memory and amnesia. The contributors discuss diagnosis, assessment and treatment issues, as well as ethical and legal considerations and topics of emerging interest such as the early detection of dementia. ...