Synthetic Applications of 13-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products
2003 | ISBN: 0471221902 | Pages: 943 | PDF | 6.44 MB
Cycloaddition reactions figure prominently in both synthetic and mechanistic organic chemistry. The current understanding of the underlying principles in this area has grown from a fruitful interplay between theory and experiment. The monumental work of Rolf Huisgen and co-workers in the early 1960s led to the general concept of 1,3-dipolar cycloaddition. Few reactions rival this process in the number of bonds that undergo transformation during the reaction, producing products considerably more complex than the reactants. Over the years, this reaction has developed into a generally useful method for five-membered heterocyclic ring synthesis, since many 1,3-dipolar species are readily available and react with a wide variety of dipolarophiles.